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An AI-Equipped Microscope Can Diagnose Deadly Blood Infections

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Categories of Interest: Select All. Published in the journal Nature Materials , the researchers demonstrated blood flow disturbance could lead to previously unrecognised intermediate activation of integrin, an adhesion receptor that mediates platelet aggregation to form a clot.

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Integrin is a mechanosensory protein that platelets use to sense mechanical force generated by dynamic blood flow. The integrin can instruct the platelet cells' clotting behaviours. The researchers say the finding -- that biomechanical thrombus growth is mainly mediated by an intermediate state triggered by a unique integrin biomechanical activation pathway -- has the potential to guide the development of new anti-thrombotic strategies.

Deadly Sinners - 3 Inches Of Blood

This could benefit many of the 55, Australians who suffer a heart attack each year -- one every 10 minutes. Ju's research also provides a new explanation for the poor efficacy of conventional anti-platelet drugs in the treatment of thrombotic cardiovascular diseases. Although these drugs inhibit the biochemical activation of platelets, they may not block the platelet biomechanical signaling pathways.

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However, these drugs have serious side effects that cause fatal bleeding," said Dr. Senior Fellow at HRI Yuping Yuan said, "Since diabetes represents the biggest threat to the Australian health system, this discovery sheds light on protecting vulnerable diabetic individuals from heart diseases.

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The "mechanically driven platelet activation" phenomenon found in the study explains why platelets can aggregate and accumulate by mechanical stimulation of high-speed turbulence alone, leading to blockage of a blood vessel. Therefore, this research provides new ideas for the development of novel and highly effective antithrombotic drugs with no serious bleeding side effects. Materials provided by University of Sydney. Note: Content may be edited for style and length. Science News.

Story Source: Materials provided by University of Sydney. Jackson, Cheng Zhu. Nature Materials , ; DOI: